Cryptorchidism is defined as the arrested development of the testis / testes
along its normal course.
It is: Unilateral in about 75% of cases and
Bilateral in 25%. Arrested
descent may occur anywhere along its pathway from the retroperitoneum to the
scrotum. 80% of undescended testes lie at or
below the level of the
inguinal ring.
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Unilateral
cryptorchidism
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Unilateral
cryptorchidism
Bilateral
cryptorchidism
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Cryptorchidism in Prune Belly Syndrome
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The diagnosis depends on Normal Testicular Descent
into the scrotum.
The diagnosis is important as the testes degenerates histologically as early
as 1-2 years of age. Both testes may be affected, even with a unilateral,
undescended testis. Cryptorchidism results in an increased risk of infertility
and testicular cancer. The risk of testicular malignancy is 10-40 fold higher
in men with cryptorchidism than in normal men.
Cryptorchidism is the most frequent anomaly of an endocrine gland, with an
incidence of 3.4% in the term newborn, and 0.8-1% at 1 year of age (1).
- Prune-belly
syndrome (bilateral cryptorchidism).
- Anorchia (bilateral
cryptorchidism).
- Noonan's
syndrome (agonadism or normal gonads).
- Trisomies
13, 18 and 21.
- Other associations include:
- Aarskfog
(facial-digital-genital)
- Androgen
insensitivity syndromes
- Anencephaly
- Cleft
lip/palate (holoprosencephaly).
- Cockayne
syndrome
- Cornelia
de Lange syndrome
- Cryptophthalamus
- Dubowitz
syndrome
- Hypopituitarism
- Kallman's
syndrome
- Laurence-Moon-Biedl
- Lowe
(oculocerebrorenal) syndrome
- Meckel-Gruber
syndrome
- Noonan
syndrome
- Optiz
syndrome
- Pituitary
aplasia-hypoplasia
- Prader-Willi
syndrome
- Prune-belly
syndrome
- Roberts
syndrome
- Rubinstein-Taybi
syndrome
- Septic-optic-dysplasia
- Smith-Lemli-Optiz
syndrome
- Testicular
enzymatic defects
- Triploidy
- Trisomy
13
- Trisomy
18
- 4p
- (Wolf-Hirschhorn)
- 5-a-reductase
deficiency
- 13
q
- 18 q
- Desgrandchamps F.
Undescended testes. Current stage of knowledge. J Urol (Paris)
1990;96:407-414.
- Rajfer J. Congenital
Anomalies of the testis. In: Walsk DC, Retick AB, Saney TA, et al. Campbell's Urology. W. B. Saunders,
Harcourt, 6th edition, 1992, pp. 1543-1562.
- Bartone FF, Schmidt MA:
Cryptorchidism: incidence of chromosomal anomalies in 50 cases. J Urol
1992;127:1105.
- Bishop MC, Whitaken, RH.
Associated renal anomalies in familial cryptorquidism (letter). Lancet
1079;2:249.
- Czeizel A, Erodi E, Toth J.
Genetics of undescended testis. J Urol 1981;126:528-529.
- Geffner ME, Lippe BM: Genetic and
endocrinologic syndromes associated with cryptorchidism. in The
undescended testis. Ed. EW Fonkalsrud, W. Mendel. Chicago, Year Book Medical Publisher,
1981