Trisomy 21 - Down Syndrome
General Features General information/Sensitivity of markers	Karyotype View
Neck * Thick nuchal fold / Nuchal edema * Increased nuchal translucency * Crown-rump length - normal * Non-immune hydrops, hydrothorax *  Cystic hygroma uncommon.	Extremities   * Shortened femur and humerus   * Clinodactyly + hypoplasia of middle phalanx of 5th digit   * Simian crease   * Sandal foot (45%) / May be a normal variant
- Craniofacial Anomalies   * Maxillary hypoplasia   * Brachycephaly   * Short nasal bone   * Macroglossia	Gastrointestinal Anomalies   * Duodenal atresia   * Esophageal atresia   * Anorectal atresia   * Echogenic bowel   * Omphalocele
Central Nervous System Anomalies   * Ventriculomegaly   * Dandy Walker Variant	Cardiac Anomalies (50%)   * ASD   * VSD   * AV Canal   * Echogenic intracardiac focus   * Fetal Heart Rate * LV / RV disproportion.
Genitourinary   * Renal pelvis dilatation (pyelectasis)	Pelvis
IUGR.	Non-lymphoblastic leukemic reaction   (hepatosplenomegaly)
Genetic Sonogram
Genetic Sonogram Template