Trisomy 18 - Edwards Syndrome
General Features [more information]	Karyotype View
IUGR	Decreased crown-rump length
Central Nervous System   * Ventriculomegaly   * Large cisterna magna   * Dandy Walker Variant   * Choroid plexus cyst ( 30% )	Genitourinary Anomalies   * Urethrovesical obstruction   * Renal agenesis / dysplasia   * Horseshoe kidney   * Ambiguous genitalia * Magacystics (first trimester)
Neck * Cystic hygroma ± non-immune hydrops * Nuchal fold (normal or increased).	Extremities   * Limb reduction   * Club feet   * Rockerbottom feet   * Overlapping fingers /  Clenched hands * Radial club hand and radial ray deficiencies * Flexion deformity of limbs
Craniofacial Abnormalities   * Low set ears   * Micrognathia   * Cleft lip or palate   * Hypotelorism   * Skull (normal, brachycephaly or strawberry skull).   * Microphthalmia (80%). * Absent nasal bone.	- Gastrointestinal Anomalies   * Esophageal atresia   * Anorectal atresia * Omphalocele * Echogenic bowel   * Diaphragmatic Hernia
Cardiac Defects (90-99%)   * VSD   * ASD   * Fetal Heart Rate	Musculo-skeletal abnormalities
Single umbilical artery	Polyhydramnios / oligohydramnios
Umbilical cord pseudocyst Hypoplastic umbilical artery Umbilical artery aneurysm Aneurysm of the umbilical vein Persistence of the right umbilical vein

REFERENCES

1. Museve NN, Alexander DJ, Teshima I et.al. Echocardiographic evaluation of the spectrum of cariac anomalies associated with trisomy 12 and trisomy 18. J An Coll Cardiol 1990; 15:673-677
2. Jackson S, Porter H, Vyas S. Trisomy 18: first-trimester nuchal translucency with pathological correlation. Ultrasound Obstet Gynecol 1995; 5:55-56